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Articles by Van Eyk
SysQuan Database: A Community Resource for System-Wide Absolute Quantitation of the Human Proteome
Proteins play a crucial role in health and disease and comprise the majority of disease biomarkers and drug targets. Mass spectrometry (MS) enables proteome-wide identification and quantitation of proteins with high specificity, precision, and unmatched specificity in virtually any type of sample, from archeological specimens to human tissue biopsies.
DOCK2 as a novel CD11c ligand in neutrophils to regulate reactive oxygen species production
ORIGINAL RESEARCH article Front. Immunol. Sec. Inflammation Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1692451 DOCK2 as a novel CD11c ligand in neutrophils to regulate reactive oxygen species production Provisionally accepted 1Boston Children's Hospital, Harvard Medical School, Boston, United States 2Cedars-Sinai Medical Center, Los Angeles, United States 3Kyushu Daigaku, Fukuoka, Japan The final, formatted version of the article will be published soon.
Unlocking the Potential of Single-Cell Omics
Journal of Proteome Research Cite this: J. Proteome Res. 2025, 24, 4 Click to copy citationCitation copied! . This publication is available under these Terms of Use. Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
An exploratory analysis of differences in serum protein expression by sex in patients with systemic sclerosis associated interstitial lung disease - BMC Pulmonary Medicine
There was a total of 211 subjects, 162 women and 47 men with similar baseline characteristics, Table 1. The median follow-up time for the cohort was 3.52 years [IQR 1.55–6.38], with 3.66 years [IQR 2.13–8.06] for men and 3.33 years [IQR 1.46–6.38] for women. During the observation period, 118 patients experienced a FVC decline of at least 5%. The median time to FVC decline was 2.14 years [IQR 0.99–3.66].
Enhanced Parkin-mediated mitophagy mitigates adverse left ventricular remodelling after myocardial infarction: role of PR-364
Despite progress in diagnosis and treatment of myocardial infarction (MI), 13% of survivors develop heart failure (HF) at 30 days and 20–30% do so at 1 year post-discharge.1 As the myocardium has high energy demands, mitochondria are required to generate 6 kg/day of adenosine triphosphate (ATP) to maintain normal cardiac contractile function,2 making the organelle critical in maintaining optimal cardiac performance.
Dysregulation of protein SUMOylation networks in Huntington’s disease R6/2 mouse striatum
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat mutation in the Huntingtin (HTT) gene. The mutation impacts neuronal protein homeostasis and cortical/striatal circuitry. SUMOylation is a post-translational modification with broad cellular effects including via modification of synaptic proteins.
Dysregulation of protein SUMOylation networks in Huntington’s disease R6/2 mouse striatum
Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by a CAG trinucleotide-repeat expansion mutation in the Huntingtin (HTT) gene.1 This leads to translation of a mutant Huntingtin (mHTT) protein containing an expanded polyglutamine repeat within the amino terminus.
Health promotion and the need to accelerate advocacy for health equity
It has been 15 years since the final report of the WHO Commission on Social Determinants of Health (CSDH)—‘Closing the Gap in a Generation’ (CSDH, 2008)—was published. While there have been gains in overall health since then, improvements in health have not been equitably distributed and there is evidence of increasing inequities within OECD countries (Hu et al., 2016; Mackenbach et al., 2018).
High sensitivity cardiac troponin I in response to handgrip in women with signs and symptoms of ischemia with no obstructive coronary arteries
Women with signs and symptoms of ischemia and no obstructive coronary arteries (INOCA) are suspected to have myocardial ischemia, ∼10% have prior myocardial scar often in the absence of acute myocardial infarction (AMI) diagnosis and the development of heart failure with preserved ejection fraction (HFpEF) is relatively frequent. The mechanisms contributing to AMI and HFpEF progression are poorly understood in INOCA.
Identification of novel biomarkers for the prediction of subclinical coronary artery atherosclerosis in patients with rheumatoid arthritis: an exploratory analysis | Arthritis Research & Therapy | Full Text
Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Care Res (Hoboken). 2008;59:1690–7. Article Google Scholar Boyer JF, Gourraud PA, Cantagrel A, Davignon JL, Constantin A. Traditional cardiovascular risk factors in rheumatoid arthritis: a meta-analysis. Joint Bone Spine. 2011;78:179–83.
Initial recommendations for performing, benchmarking and reporting single-cell proteomics experiments
Nature Methods, Apr 2023 This is a preview of a remote PDF: https://www.nature.com/articles/s41592-023-01785-3.pdf Gatto, Laurent, Aebersold, Ruedi, Cox, Juergen, Demichev, Vadim, Derks, Jason, Emmott, Edward, Franks, Alexander M., Ivanov, Alexander R., Kelly, Ryan T., Khoury, Luke, Leduc, Andrew, MacCoss, Michael J., Nemes, Peter, Perlman, David H., Petelski, Aleksandra A., Rose, Christopher M., Schoof, Erwin M., Van Eyk, Jennifer, Vanderaa, Christophe, Yates, John R., Slavov, Nikolai.
Retinal pathological features and proteome signatures of Alzheimer’s disease - Acta Neuropathologica
Abstract Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progression in the brain remain largely unknown. To better understand the pathological features of AD in the retina, we conducted an extensive histopathological and biochemical investigation of postmortem retina and brain tissues from 86 human donors.
Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis
Altan Rentsendorj1, Koen Raedschelders2, Dieu-Trang Fuchs1, Julia Sheyn1, Vineet Vaibhav2, Rebecca A. Porritt3, 4, Haoshen Shi1, Jargalsaikhan Dagvadorj5, Juliana De Freitas Germano2, Yosef Koronyo1, Moshe Arditi4, Keith L.
Prospective changes in diastolic function in patients with rheumatoid arthritis - Arthritis Research & Therapy
Patients The RHYTHM cohort [16, 17] was originally designed as a cross-sectional study in 2011 to identify myocardial phenotypes in RA patients without clinical CVD and then extended to include a follow-up visit 4–6 years later to study echocardiographic changes in LV structure and function. Inclusion criteria were age ≥ 18 years and fulfillment of the American College of Rheumatology/European League Against Rheumatism 2010 classification criteria for RA [18].
Promoting action on structural drivers of health inequity: principles for policy evaluation
Background: Insufficient progress has been made towards reducing health inequities, due in part to a lack of action on the root causes of health inequities. At present, there is a limited evidence base to guide policy decision making in this space. Key points for discussion: This paper proposes new principles for researchers to conduct health equity policy evaluation.
References Biller, P., Ross, A. 2011. Potential yields and properties of oil from the hydrothermal liquefaction of microalgae with different biochemical content. Bioresour Technol, 102: 215–225. Article Google Scholar Billing, J., Anderson, D., Hallen, R., Hart, T., Maupin, G., Schmidt, A., Elliott, D. 2016. Design, fabrication, and testing of the modular hydrothermal liquefaction system (MHTLS). In: Proceedings of the 2016 Symposium on Thermal and Catalytic Sciences for Biofuels and Biobased Products.
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines - Nature Neuroscience
Abstract Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This resource provides population-level biological and clinical data that may be employed to identify clinical–molecular–biochemical subtypes of amyotrophic lateral sclerosis (ALS).
Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease - Nature Communications
Abstract MATα1 catalyzes the synthesis of S-adenosylmethionine, the principal biological methyl donor. Lower MATα1 activity and mitochondrial dysfunction occur in alcohol-associated liver disease. Besides cytosol and nucleus, MATα1 also targets the mitochondria of hepatocytes to regulate their function. Here, we show that mitochondrial MATα1 is selectively depleted in alcohol-associated liver disease through a mechanism that involves the isomerase PIN1 and the kinase CK2.
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection - Journal of Translational Medicine
In this study, comprehensive profiling of AAB activation in 177 HCs with prior SARS-CoV-2 infection revealed several important sex-specific findings of interest. First, a surprisingly large number of the diverse autoantibodies assayed were differentially activated in males compared to females.
Developing a Framework for a Program Theory-Based Approach to Evaluating Policy Processes and Outcomes: Health in All Policies in South Australia
Document Type: Original Article Authors Angela Lawless 1 Fran Baum 2 Toni Delany-Crowe 2 Colin MacDougall 3 Carmel Williams 4 Dennis McDermott 5 Helen van Eyk 2 1 College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia 2 Southgate Institute for Health Society and Equity, Flinders University, Adelaide, SA, Australia 3 College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia 4 Department of Health and Ageing, Adelaide, SA, Australia 5 The...
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