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Articles by van Hellemond
Neoadjuvant chemo-reirradiation followed by resection and intraoperative electron beam radiotherapy: outcomes of multimodality treatment for locally recurrent rectal cancer | Radiation Oncology | Springer Nature Link
Detering R, Karthaus EG, Borstlap WAA, van de Marijnen CAM, Bemelman WA, et al. Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial. Eur J Surg Oncol. 2019;45(11):2059–69. Google Scholar van Gijn W, Marijnen CA, Nagtegaal ID, Kranenbarg EM, Putter H, Wiggers T, et al.
Evaluation of potential biomarkers during irinotecan-based systemic treatment for colorectal cancer—study protocol of the OPTIMA study - BMC Cancer
To the best of our knowledge, the OPTIMA study will be the first study to evaluate tumor molecular profiling, UGT1A1 genotype and GUS activity as potential biomarkers for efficacy and toxicity of irinotecan-based systemic treatment in patients with advanced CRC.
Plasmodium falciparum malaria runs a more severe course in splenectomized patients at comparable levels of parasitemia: a retrospective matched case-control study | Tropical Diseases, Travel Medicine and Vaccines
Abstract The spleen plays a vital role in combating Plasmodium infections, particularly during the erythrocytic stage of the infection. Asplenia may notably affect disease progression and parasite clearance dynamics. More insight is needed as to whether asplenic malaria patients - beyond considerations of parasite load - also face a higher burden of disease caused by malaria-specific manifestations of organ dysfunction and/or metabolic deterioration.
Locally recurrent rectal cancer: Oncological outcomes for patients with a pathological complete response after neoadjuvant therapy
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Locally recurrent rectal cancer: Oncological outcomes for patients with a pathological complete response after neoadjuvant therapy
For patients with locally recurrent rectal cancer, it is an ongoing pursuit to establish factors predicting or improving oncological outcomes. In locally advanced rectal cancer, a pCR appears to be associated with improved outcomes. The aim of this retrospective cohort study was to compare the oncological outcomes of patients with locally recurrent rectal cancer with and without a pCR.
Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?
Numerous human pathogens express AOX, the activity of which facilitates a number of vital functions in the pathogen adaptation processes, which in turn can enhance their pathogenicity. One example is in Trypanosoma brucei (a causative agent of trypanosomiasis), where AOX plays a crucial role in adapting the metabolism to facilitate its life-cycle either in the tsetse fly (genus Glossina) or within the human bloodstream.
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