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Van Het Hoog

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Articles

Inheritance of epigenetic transcriptional memory through read-write replication of a histone modification

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By Jason H. Brickner, de Maeyer, Di Croce, Van Het Hoog
| Wiley Online Library Verified
CHROMATIN AS A SOURCE OF HERITABLE TRANSCRIPTIONAL MEMORY Could H3K4me2 be the source of epigenetically heritable information? In other words, is H3K4me2 inherently stable and capable of being re-established after DNA replication? We first assessed the stability of H3K4me2 associated with active transcription by examining this mark over the INO1 promoter in a mutant that lacks memory.
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