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Articles by van Loo
Leishmania infantum triggers lipid peroxidation and non-canonical cell death in macrophages
Abstract Leishmania infantum is a causative agent of visceral leishmaniasis and survives as an obligate intracellular parasite within macrophages by modulating host cell death pathways. While preservation of host cell viability is critical for parasite replication, infected macrophages ultimately undergo cell death, although the mechanisms remain unclear. Here, we investigated the nature of L. infantum-induced cell death in murine bone marrow-derived macrophages (BMDMs).
Condensed Matter > Mesoscale and Nanoscale Physics
A recent experiment reported coherent parity oscillations between minimal Kitaev chains, demonstrating a Majorana parity qubit (arXiv:2607.09511). Operations on this qubit are controlled by coupling two Kitaev chains and are intrinsically unprotected against noise in the coupling strength. Here we show how the exponential protection in the underlying chains can nevertheless be revealed through unprotected qubit operations.
Mathematics > Number Theory
We investigate restrictions on the dimensions and coordinate fields of real Weyl-Heisenberg fiducial vectors. Our main result is that such vectors can exist only in dimensions $d\equiv 3\pmod{4}$. This result is motivated by evidence showing that real Weyl-Heisenberg fiducial vectors can exist only in dimensions $d = 4m^2 + 3, m \in \mathbb{Z}_{\geq 0}$.
High Energy Physics - Experiment
[Submitted on 3 Sep 2026 (v1), last revised 8 Oct 2026 (this version, v2)] View PDF HTML (experimental) Subjects: High Energy Physics - Experiment (hep-ex) Cite as: arXiv:2609.03879 [hep-ex] (or arXiv:2609.03879v2 [hep-ex] for this version) https://doi.org/10.48550/arXiv.2609.03879
Computer Science > Information Retrieval
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment
Yang, Xinyu, Liu, Wei, Macintyre, Geoff, Van Loo, Peter, Markowetz, Florian, Bailey, Peter ORCID: https://orcid.org/0000-0002-0857-2041 and Yuan, Ke ORCID: https://orcid.org/0000-0002-2318-1460 (2026) Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment. Cell Reports, 45(3), 117098. (doi: 10.1016/j.celrep.2026.117098) (PMID:41832954) Text 380450.pdf - Published Version Available under License Creative Commons Attribution.
Live-cell physiology in human brain tissue culture—the potential, the challenges, and the lessons learned
Abstract A growing number of studies are now utilizing human organotypic brain slice cultures (OBSC), enabled by improved long-term culture protocols that support the investigation of human-specific cellular physiology. Human OBSC offer the unique advantage, that they preserve the connectivity and microenvironment of human brain tissue while remaining experimentally tractable for live functional assays.
From Mice to Clinical Relevance: Humanizing Neuroscience with Human-Based Model Systems
REVIEW article Volume 20 - 2026 | doi: 10.3389/fncel.2026.1776439 Reviewed by REVIEW article AV Aniella Vanessa Bak 1 KM Karen M. J. van Loo 1,2 DK Deborah Kronenberg-Versteeg 3,4 HK Henner Koch 1 1. Department of Epileptology, Neurology, RWTH University Hospital Aachen, Aachen, Germany 2. Department of Neurosurgery, RWTH University Hospital Aachen, Aachen, Germany 3. Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany 4.
Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study - BMC Medicine
In this large population-based study, we found robust familial co-aggregation between FDs/IDs and two major disease groups. First, we found significant familial co-aggregation between all studied FDs/IDs and immune-related diseases.
Fast Multiplexed Superconducting-Qubit Readout with Intrinsic Purcell Filtering Using a Multiconductor Transmission Line
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä This publication is imported from Aalto University research portal. View publication in the Research portal (opens in new window) View/Open full text file from the Research portal (opens in new window) Other link related to publication (opens in new window) PRX Quantum, Volume 6, issue 2, pp. 1-23 Publisher Copyright: © 2025 authors. Published by the American Physical Society.
Condensed Matter > Mesoscale and Nanoscale Physics
[Submitted on 2 Jul 2025 ( v1 ), last revised 6 Oct 2026 (this version, v2)] Title:Single-shot parity readout of a minimal Kitaev chain Authors:Nick van Loo , Francesco Zatelli , Gorm O. Steffensen , Bart Roovers , Guanzhong Wang , Thomas Van Caekenberghe , Alberto Bordin , David van Driel , Yining Zhang , Wietze D. Huisman , Ghada Badawy , Erik P.A.M. Bakkers , Grzegorz P. Mazur , Ramón Aguado , Leo P.
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding
Jans, M. et al. (2024) Colibactin-driven colon cancer requires adhesin-mediated epithelial binding. Nature, 635(8038), pp. 472-480. (doi: 10.1038/s41586-024-08135-z) (PMID:39506107) Full text not currently available from Enlighten. Abstract Various bacteria are suggested to contribute to colorectal cancer (CRC) development1,2,3,4,5, including pks+ Escherichia coli, which produces the genotoxin colibactin that induces characteristic mutational signatures in host epithelial cells6.
Reference files for ASCAT
DOI 10.5281/zenodo.14008443 Markdown [](https://doi.org/10.5281/zenodo.14008443) reStructuredText ..
NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells
Cell Death and Differentiation, Oct 2024 IKK signalling is essential for survival of thymocytes by repressing RIPK1 induced cell death rather than its canonical function of activating NF-κB. The role of IKK signalling in activated T cells is unclear. To investigate this, we analysed activation of IKK2 deficient T cells. While TCR triggering was normal, proliferation and expansion was profoundly impaired.
Data from: Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice
DOI 10.5061/dryad.s4mw6m9dr Markdown [](https://doi.org/10.5061/dryad.s4mw6m9dr) reStructuredText ..
Celebrating Women in Science: Pioneering Contributions to Animal Behaviour and Welfare
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Van Loo, J.
Joseph Van Loo is the Director of Technical and Customer Services for the Industrial FOAMGLAS business at Owens Corning. Van Loo has more than 30 yr of experience in industrial insulation and is a member of several insulation working groups in Europe.
Do not overlook the base when insulating hot storage tanks
Do not overlook the base when insulating hot storage tanks Hot storage tanks in petrochemical facilities, terminals and industrial sites globally house valuable and often volatile products, including organic liquids, raw materials, intermediate fuels and byproducts. IP: 66.228.36.104 The Authors Schraeyen, S. - Owens Corning, Beringen, Belgium Steffen Schraeyen is a Technical Product Lead for the Industrial FOAMGLAS® business at Owens Corning.
Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine - Genome Medicine
We utilized whole genome sequencing data together with 3D anatomic and histomorphologic information from two men (GP5 and GP12) with high-risk PrCa undergoing radical prostatectomy to reconstruct the evolution of their cancers. A total of 22 sites were profiled from both patients, including multiple samples from the prostate, sites of spread to the SV, and pelvic LN metastases (Figs. 1 and 2, Additional file 1: Figs. S1, and S2).
Amazon's Pricing Paradox
Abstract Antitrust scholars have widely debated the apparent paradox of Amazon seemingly wielding monopoly power while offering low prices to consumers. A single company’s behavior thereby helped spark an intellectual renaissance as scholars debated why Amazon’s prices were so low, whether antitrust enforcers should intervene, and, eventually, how the field should be reformed for the era of large online platforms.
Why All Healthy Laboratory Animals Should Be Rehomed, No Matter How Small
1. Introduction Rehoming laboratory animals that are alive and healthy after animal experiments, or that have not been used and are surplus, is common practice in animal laboratories. However, this is especially true for larger companion animal species. As normal as it seems to grant cats, dogs and horses a good life after the lab, it seems normal to routinely kill smaller surplus animals such as mice and rats [1,2,3]. This has probably to do with how we were raised: our culture.
Frontiers | The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice
1 Introduction Inflammasomes are multiprotein complexes that serve as a platform for inflammatory caspase activation. During canonical inflammasome activation, detection of pathogen-associated or danger-associated molecular patterns (PAMPs/DAMPs) by cytosolic sensor proteins leads to recruitment and proteolytic activation of caspase-1. Subsequently, activated caspase-1 proteolytically matures the proinflammatory cytokines pro-IL-1β and pro-IL-18, and cleaves Gasdermin D (GSDMD).
Frontiers | Rituximab and improved nodular regenerative hyperplasia-associated non-cirrhotic liver disease in common variable immunodeficiency: a case report and literature study
1 Introduction Common variable immunodeficiency (CVID) is the most common primary immunodeficiency in adulthood and is characterized by a defective B cell differentiation, impaired antibody secretion and recurrent bacterial infections. More than 30% of patients also suffer from non-infectious comorbidities attributed to immune dysregulation. These have become the leading cause of death in CVID since immunoglobulin replacement therapy is insufficient to prevent or control their complications.
Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies
In 1914, Theodor Boveri hypothesized that irreparable defect in chromosomes leads to the malignant transformation (1). Experimental evidence in 1970s to 1980s suggested that the acquisition of stepwise mutational events in a normal cell can cause transformation into an indefinitely dividing cell (2–4). Subsequent genomic studies found that all tumor cells share a set of genomic mutations, implying a single, most recent common ancestor (MRCA; ref. 5).
Amazon's Pricing Paradox
45 Pages Posted: 14 May 2023 Last revised: 27 Sep 2023 Date Written: May 2, 2023 Keywords: platform regulation, Amazon, dark patterns, electronic commerce, behavioral economics, open retail Suggested Citation: Suggested Citation Van Loo, Rory and Aggarwal, Nikita, Amazon's Pricing Paradox (May 2, 2023). Harvard Journal of Law & Technology, Forthcoming, Available at SSRN: https://ssrn.com/abstract=4436546
COVID-19 pandemic response in the Meuse-Rhine Euroregion: methods, participation and recommendations of a longitudinal cross-border study - Archives of Public Health
Table 1 presents the population - versus sample distribution per age group in the Meuse-Rhine Euroregion. Participation in round 1 In total, 26,925 citizens in the EMR received an invitation to participate in the study. Three hundred twenty invitations never arrived at their destination: 250 in Germany, 46 in Belgium and 24 in the Netherlands. The opt-out rate in South Limburg (NL) was 33.7% (2,358 opt-outs) in the initial sample and 38.2% (1,638 opt-outs) in the reserve sample.
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Nature Genetics, Apr 2023 This is a preview of a remote PDF: https://www.nature.com/articles/s41588-023-01319-9.pdf Rodriguez-Martin, Bernardo, Alvarez, Eva G., Baez-Ortega, Adrian, Zamora, Jorge, Supek, Fran, Demeulemeester, Jonas, Santamarina, Martin, Ju, Young Seok, Temes, Javier, Garcia-Souto, Daniel, Detering, Harald, Li, Yilong, Rodriguez-Castro, Jorge, Dueso-Barroso, Ana, Bruzos, Alicia L., Dentro, Stefan C., Blanco, Miguel G., Contino, Gianmarco, Ardeljan, Daniel, Tojo, Marta,...
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution - Genome Biology
The MEDICC2 model To solve the MED problem, we employ a finite-state transducer (FST) framework as previously described [6], following the notation of Mohri [63] (Additional file 1: Fig. S1a). Copy-number profiles are represented as vectors of positive integer copy numbers (k)1. . n , with 0 ≤ k ≤ 8 , where each integer copy number represents a genomic segment i.
Privacy Pretexts
49 Pages Posted: 8 Mar 2022 Last revised: 25 Apr 2022 Date Written: March 3, 2022 Abstract Data privacy’s ethos lies in protecting the individual from institutions. Increasingly, however, institutions are deploying privacy arguments in ways that harm individuals. Platforms like Amazon, Facebook, and Google wall off information from competitors in the name of privacy.
Biallelic mutations in cancer genomes reveal local mutational determinants - Nature Genetics
Abstract The infinite sites model of molecular evolution posits that every position in the genome is mutated at most once1. By restricting the number of possible mutation histories, haplotypes and alleles, it forms a cornerstone of tumor phylogenetic analysis2 and is often implied when calling, phasing and interpreting variants3,4 or studying the mutational landscape as a whole5.
The use of food swaps to encourage healthier online food choices: a randomized controlled trial - International Journal of Behavioral Nutrition and Physical Activity
Abstract Background Online grocery stores offer opportunities to encourage healthier food choices at the moment that consumers place a product of their choice in their basket. This study assessed the effect of a swap offer, Nutri-Score labeling, and a descriptive norm message on the nutrient profiling (NP) score of food choices in an online food basket.
Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes - Nature Communications
Abstract Black women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white women of European ancestry. Although inter-ethnic germline variation is known, differential somatic evolution has not been investigated in detail.
Shadow-wall lithography of ballistic superconductor–semiconductor quantum devices - Nature Communications
Abstract The realization of hybrid superconductor–semiconductor quantum devices, in particular a topological qubit, calls for advanced techniques to readily and reproducibly engineer induced superconductivity in semiconductor nanowires. Here, we introduce an on-chip fabrication paradigm based on shadow walls that offers substantial advances in device quality and reproducibility.
Microbes exploit death-induced nutrient release by gut epithelial cells - Nature
Abstract Regulated cell death is an integral part of life, and has broad effects on organism development and homeostasis1. Malfunctions within the regulated cell death process, including the clearance of dying cells, can manifest in diverse pathologies throughout various tissues including the gastrointestinal tract2.
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade - Nature Communications
Abstract Immune checkpoint inhibitors demonstrate clinical activity in many tumor types, however, only a fraction of patients benefit. Combining CD137 agonists with these inhibitors increases anti-tumor activity preclinically, but attempts to translate these observations to the clinic have been hampered by systemic toxicity. Here we describe a human CD137xPD-L1 bispecific antibody, MCLA-145, identified through functional screening of agonist- and immune checkpoint inhibitor arm combinations.
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia - Nature Cancer
Abstract Comparison of intratumor genetic heterogeneity in cancer at diagnosis and relapse suggests that chemotherapy induces bottleneck selection of subclonal genotypes. However, evolutionary events subsequent to chemotherapy could also explain changes in clonal dominance seen at relapse. We therefore investigated the mechanisms of selection in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) during induction chemotherapy where maximal cytoreduction occurs.
Kinetiq News Article
When Meredith Koch arrives at Boston Sports Institute (BSI) for practice a few times a week with her Paralympic swim team, she never takes for granted how easy it is for her to park, enter the building and get in the pool. Restrooms are big and easy for her to access. Parking is abundant. And the pool's design and its spacious deck allow swimmers who require wheelchairs to access the area with ease. For her, BSI is different.
In Defense of Breakups: Administering a 'Radical' Remedy
49 Pages Posted: 9 Jul 2020 Last revised: 31 Aug 2020 Abstract Calls for breaking up monopolies — especially Amazon, Facebook, and Google — have largely focused on proving that past acquisitions of companies like Whole Foods, Instagram, and YouTube were anti-competitive. But scholars have paid insufficient attention to another major obstacle that also explains why the government in recent decades has not broken up a single large company.
Federal Rules of Platform Procedure
Abstract Tech platforms serve as private courthouses for disputes about speech, lodging, commerce, elections, and reputation. After receiving allegations of defamatory content in top search results, Google must decide between protecting one person’s public image and another’s profits or speech. Amazon adjudicates disputes between consumers and third-party merchants about defective or counterfeit items. For many small businesses, layoffs and bankruptcy hang in the balance.
Applied bioinformatics for the identification of regulatory elements
Abstract The compilation of multiple metazoan genome sequences and the deluge of large-scale expression data have combined to motivate the maturation of bioinformatics methods for the analysis of sequences that regulate gene transcription. Historically, these bioinformatics methods have been plagued by poor predictive specificity, but new bioinformatics algorithms that accelerate the identification of regulatory regions are drawing disgruntled users back to their keyboards.
BACE2 distribution in major brain cell types and identification of novel substrates
Voytyuk, I; Mueller, SA; Herber, J; Snellinx, A; Moechars, D; van Loo, G; Lichtenthaler, SF; Voytyuk, I; Mueller, SA; Herber, J; Snellinx, A; Moechars, D; van Loo, G; Lichtenthaler, SF; De Strooper, B; - view fewer (2018) BACE2 distribution in major brain cell types and identification of novel substrates. Life Science Alliance , 1 (1) , Article e201800026. 10.26508/lsa.201800026.
Genomic Classification and Prognosis in Acute Myeloid Leukemia
39 References 1336 Citing Articles Letters 2 Comments Related Articles Abstract Background Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice. Methods We enrolled a total of 1540 patients in three prospective trials of intensive therapy.
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