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Vangeli Geshkovski on Muck Rack

Vangeli Geshkovski

As seen in: Nature, BioRxiv
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Articles

The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions

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By Vangeli Geshkovski, Julia Engelhorn, Jean-Baptiste Izquierdo, Hamida Laroussi, Laura Turchi, Meredith Wouters, Marie Le Masson, Emmanuel Thevenon, Ambre Petitalot, Lauriane Simon, Manon Verdier, Sophie Desset, Astrid Bruckmann, Hugues Parrinello, Klaus D. Grasser, Aline V. Probst, Raphaël Margueron, Gilles Vachon, Jan Kadlec, Cristel C CARLES, Caroline Thouly, Philipp Michl-Holzinger
| Nature Verified
Abstract The antagonistic POLYCOMB (PcG) REPRESSIVE COMPLEX 2 (PRC2) and trithorax (trxG) chromatin machineries orchestrate gene expression during the development of multicellular eukaryotes. These complexes deposit and maintain the repressive trimethyl mark on H3K27 and the activating trimethyl mark on H3K4, respectively. However, the mechanisms governing the switch between these functions remain elusive, especially in plants, whose lifelong, flexible development relies heavily on this process.
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The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions

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By Julia Engelhorn, Hamida Laroussi, Vangeli Geshkovski, Jean-Baptiste Izquierdo
| BioRxiv
Abstract The antagonistic POLYCOMB (PcG) REPRESSIVE COMPLEX 2 (PRC2) and trithorax (trxG) chromatin machineries play a major role in orchestrating gene expression during the development of multicellular eukaryotes. These complexes are well known for depositing and maintaining the repressive H3K27me3 and activating H3K4me3 marks, respectively.
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