Vanitha Nithianadam

2,5 1 Harvard Medical School, Brigham and Women's Hospital; 2 Brigham and Women's Hospital; 3 Harvard Medical School; 4 Massachusetts Institute of Technology ↵* Corresponding author; email: mel_feany{at}hms.harvard.edu Received September 29, 2023. Accepted April 4, 2024. This manuscript is Open Access. This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International license), as described at http://creativecommons.org/licenses/by/4.0/.

Abstract Neuromuscular disorders caused by dysfunction of the mitochondrial respiratory chain are common, severe and untreatable. We recovered a number of mitochondrial genes, including electron transport chain components, in a large forward genetic screen for mutations causing age-related neurodegeneration in the context of proteostasis dysfunction.