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Varvara Mathiopoulou on Muck Rack

Varvara Mathiopoulou

As seen in: Nature, MDPI, medRxiv
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Articles

Identifying maximal beta power from directional subthalamic local field potentials in Parkinson’s disease

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By Jennifer Behnke, Robert Peach, Moritz Gerster, Richard M. Köhler, Jeroen Habets, Johannes Busch, Varvara Mathiopoulou, Jonathan Kaplan, Lucia K. Feldmann, Chi Wang Ip, Katharina Faust, Patricia Krause, Andrea Kuhn, Juliette Vivien, Gerd-Helge Schneider
| Nature Verified
Abstract Accurate subthalamic beta activity could guide deep brain stimulation programming in Parkinson’s disease, but bipolar recordings complicate contact selection. In 39 patients, we validated three methods to estimate pseudo-monopolar beta power. Distance-weighted methods (Euclidean, Strelow) agreed consistently with the externalized “ground-truth” beta distribution. Maximal beta power across 20s windows was more stable in ring than in directional channels.
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DBS-induced gamma entrainment as a new biomarker for motor improvement with neuromodulation

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By Varvara Mathiopoulou, Jeroen Habets, Lucia Katharina Feldmann, Johannes Busch
| medRxiv
A.A.K. received honoraria for consultancies and/or talks from Medtronic, Boston Scientific, and Stada Pharm. L.K.F. received honoraria for consultancies/talks from Medtronic. The remaining authors report no competing interests.
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Modulation of subthalamic beta oscillations by movement, dopamine, and deep brain stimulation in Parkinson’s disease - npj Parkinson's Disease

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By Varvara Mathiopoulou, Roxanne Lofredi, Lucia K. Feldmann, Natasha Darcy, Wolf-Julian Neumann
| Nature Verified
Abstract Subthalamic beta band activity (13–35 Hz) is known as a real-time correlate of motor symptom severity in Parkinson’s disease (PD) and is currently explored as a feedback signal for closed-loop deep brain stimulation (DBS). Here, we investigate the interaction of movement, dopaminergic medication, and deep brain stimulation on subthalamic beta activity in PD patients implanted with sensing-enabled, implantable pulse generators.
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