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Vassiliki Saloura

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Articles

Oncogenic and immunomodulatory functions of SUV420H1 in HPV-negative head and neck squamous cell carcinoma

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By Arfa Moshiri, Marie Luff, Meiye Jiang, Mohd Saleem Dar, Malhar Patel, Katherine M. McKinnon, Elijah F. Edmondson, Laura L. Bassel, Andrew Warner, Jawad Akhtar, Hui Cheng, Ken Matsui, Sohyoung Kim, Jocelyn Bassler, Vassiliki Saloura
| Nature Verified
Abstract Despite the advent of immunotherapy, human-papilloma-virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) carries a high morbidity and mortality rate, thus novel therapies are urgently needed. Suppressor Of Variegation 4-20 Homolog 1 (SUV420H1) is a protein lysine methyltransferase that writes H4K20me3. Approximately 35% of HPV-negative HNSCC tumors carry gains/amplifications of SUV420H1.
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