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Veeraya Bamrung

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Articles

Divergent porcine astrovirus 4: distinct respiratory and gastrointestinal clades with genetic differences

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By Phillip Gauger, Michael C Rahe, Ganwu Li, Rachel J. Derscheid, Michael Zeller, Veeraya Bamrung
| Nature Verified
Abstract In 2016, porcine astrovirus 4 (PoAstV4), historically associated with gastrointestinal infections, was first reported in piglets with acute respiratory disease in Oklahoma. Cases of PoAstV4 with consistent respiratory epitheliotropic viral lesions were later confirmed in 2023. Analyses of 38 new whole genomes indicate that respiratory-associated PoAstV4 strains are genetically distinct from those found associated with gastrointestinal disease, with a divergence of approximately 22.5–26%.
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