Velez Gomez

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by degeneration of upper and lower motor neurons in the motor cortex, brainstem, and spinal cord, leading to muscle weakness, paralysis, and respiratory failure. Despite decades of research, its etiology and pathophysiology remain only partially understood. The disease shows marked clinical, genetic, and prognostic heterogeneity, suggesting combined genetic, epigenetic, and environmental influences.

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