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Venu VG Saralamma on Muck Rack

Venu VG Saralamma

As seen in: BioRxiv
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Articles

NRF2 translation block by inhibition of cap-dependent initiation sensitizes lymphoma cells to ferroptosis and CAR-T immunotherapy

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By Marco Russo, Alicia Martinez, Paola Manara, Venu VG Saralamma
| BioRxiv
Abstract Cancers coopt stress-response pathways to drive oncogenesis, dodge immune surveillance, and resist cytotoxic therapies. Several of these provide protection from ferroptosis, iron-mediated oxidative cell death. Here, we found dramatic sensitization to ferroptosis upon disruption of cap-dependent translation in diffuse large B-cell lymphoma (DLBCL).
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