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Articles

Early functional reactivity to a CEACAM5 x CD3 T cell bispecific antibody in solid tumors associates with baseline immune contexture rather than target antigen density alone

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By Sabine Wilson, Abraham Silva, Martha L. Serrano-Serrano, Inja Waldhauer, Elisa D’Arcangelo, Matthias Lutolf, Nikolche Gjorevski, Vaios Karanikas, Anne Schoenle, Vered Bar, Seth J. Salpeter
| Nature Verified
Abstract Clinical translation of T cell bispecific (TCB) therapies in solid tumors is hindered by the immunosuppressive tumor microenvironment and intratumoral heterogeneity, features poorly captured by standard preclinical models.
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