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Vernon Justice Ebegboni

As seen in: BioRxiv
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Articles

ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3

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By Tamara Jones, Tayvia Brownmiller, Vernon Justice Ebegboni, Patrick X Zhao
| BioRxiv
Abstract The mechanistic basis for the metastasis of Ewing sarcomas remains poorly understood, as these tumors harbor few mutations beyond the chromosomal translocation that initiates the disease. Instead, the epigenome of Ewing sarcoma (EWS) cells reflects the regulatory state of genes associated with the DNA binding activity of the fusion oncoprotein's EWSR1::FLI1 or EWSR1::ERG.
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