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Vesna Boraska Perica

As seen in: Nature
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Articles

Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto’s thyroiditis

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By Yong Li, Bjørn Olav Åsvold, Joshua C. Denny, Lars G. Fritsche, Masahiro Kanai, Ilze Konrade, Graham P Leese, Eirini Marouli, Andres Metspalu, Marta R. Moksnes, Bhramar Mukherjee, Yukinori Okada, Colin Palmer, Areti Papadopoulou, Raitis Peculis, Vita Rovite, Peter Sauer, Enrique Soto-Pedre, Sundararajan Srinivasan, Inga Steinbrenner, Maris Teder-Laving, Bin Wang, Antoine Weihs, Chenjie Zeng, Jin Zhou, Xicheng Song, Lynn B Jorde, Marco Medici, Alexander Teumer, Melissa N. Bujnis, Rosalie B. T. M. Sterenborg, Vesna Boraska Perica, Anav Babbar
| Nature Verified
Abstract Autoimmune hypothyroidism (Hashimoto’s thyroiditis) is common and has a strong genetic component. Here we performed multi-ancestry genome-wide association meta-analyses encompassing 48,694 Hashimoto’s thyroiditis cases, using a precise case definition, and 1,044,134 controls. We identified 155 significant (P < 5 × 10−8) independent genetic associations, of which 45 variants and 19 loci were not previously associated with hypothyroidism.
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