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Victoria Adedoyin on Muck Rack

Victoria Adedoyin

As seen in: BioRxiv
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Articles

How the microbiome liberates iron from heme

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By Arnab Kumar Nath, Emmanuel Akpoto, Mensur Dlakić, Victoria Adedoyin
| BioRxiv
Abstract The microbiome is a hidden organ system with diverse metabolic roles. Using Bacteroides thetaiotaomicron (B theta) as a model, we asked how microbiome species process iron, the quintessential biometal supporting respiration and life as we know it, when iron is provided in complex with protoporphyrin IX (PPIX) as heme. Canonical pathways for reclaiming heme-iron from host cells or the diet require O2, which is unavailable in the GI tract and many pathological microenvironments.
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