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Vidhant Pal

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Articles

Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function

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By Casey Bauchle, Kristen E. Rohli, Cierra K. Boyer, Vidhant Pal
| Diabetes Magazine Verified
Islet Studies Abstract The defining feature of pancreatic islet β-cell function is the precise coordination of changes in blood glucose levels with insulin secretion to regulate systemic glucose homeostasis. While ATP has long been heralded as a critical metabolic coupling factor to trigger insulin release, glucose-derived metabolites have been suggested to further amplify fuel-stimulated insulin secretion.
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