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Vijayan Manoharan on Muck Rack

Vijayan Manoharan

As seen in: Chemistry World
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Articles

Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments

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By Arghya Paul, Vijayan Manoharan, Dorothee Krafft
| Chemistry World Verified
The ability to modulate stem cell differentiation in a three dimensional (3D) microenvironment for bone tissue engineering in absence of exogenous pharmaceutical agents such as bone morphogenic protein (BMP-2) remains a challenge. In this study, we introduce extracellular matrix (ECM)-mimicking nanocomposite hydrogels to induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) for bone regeneration in absence of any osteoinducting factors.
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Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

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By Vijayan Manoharan, Settimio Pacelli, Anna Desalvo
| Chemistry World Verified
Host body response to a foreign medical device plays a critical role in defining its fate post implantation. It is thus important to control host–material interactions by designing innovative implant surfaces. In the recent years, biochemical and topographical features have been explored as main target to produce this new type of bioinert or bioresponsive implants.
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