Eli Lilly is studying retatrutide in several phase-3 clinical trials for obesity, type-2 diabetes, knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatosis liver disease. Social media has been abuzz about retatrutide, a weight-loss drug that is in late clinical trials but is already being seen by medical experts as the next big leap in the treatment of diabetes and obesity.