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Vikram Ayinampudi on Muck Rack

Vikram Ayinampudi

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Articles

Cell-type-targeted mitochondrial transplantation rescues cell degeneration

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By Temurkhan Ayupov, Verónica Moreno-Juan, Serena Curtoni, Alex Fratzl, Upnishad Sharma, Susana Posada-Céspedes, Ramona Flavia Ratiu, Rei K. Morikawa, Alexandra Meyer Verified, Margherita Pezzoli, Glenn R. Bantug, Morgan Y. E. Chevalier, Yanyan Hou, Sarah Nadeau, Álvaro Herrero-Navarro, Vikram Ayinampudi, Elizabeth Kastanaki, Natasha Whitehead, Rebecca A. Siwicki, Mariana Ribeiro Verified, Annalisa Bucci, Christoph Hess, Simone Picelli, Magdalena Renner, Daniel Muller, Daniel Müller, Cameron Cowan, Simon Hansen, Botond Roska
| Nature Verified
Abstract A number of currently untreatable diseases, including neurodegenerative disorders, optic nerve atrophy and heart failure, are associated with mitochondrial dysfunction. Transplantation of healthy mitochondria has been proposed as a potential therapeutic strategy1,2,3. However, the lack of methods to target donor mitochondria to disease-affected cell types limits treatment specificity and efficacy.
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