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Viktor Hundtofte Mebus on Muck Rack

Viktor Hundtofte Mebus

As seen in: BioRxiv
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Articles

Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase

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By Maria Disen Barbuti, Eivind Frøyland Skjennum, Viktor Hundtofte Mebus, Danae Morales Angeles
| BioRxiv
Abstract Regulated protein degradation by Clp proteases is a highly conserved post-translational control mechanism in bacteria. In Staphylococcus aureus, the ClpXP complex targets the peptidoglycan hydrolase Sle1, maintaining a tightly regulated balance between peptidoglycan biosynthesis and hydrolysis, which is required to ensure proper cell splitting without compromising cell integrity. β-lactams antibiotics disturb this balance, leading to their bactericidal effects.
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Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase

|
By Maria Disen Barbuti, Viktor Hundtofte Mebus, Eivind Frøyland Skjennum, Danae Morales Angeles
| BioRxiv
Abstract Regulated protein degradation by Clp proteases is a highly conserved post-translational control mechanism in bacteria. In Staphylococcus aureus, the ClpXP complex targets the peptidoglycan hydrolase Sle1, maintaining a tightly regulated balance between peptidoglycan biosynthesis and hydrolysis, which is required to ensure proper cell splitting without compromising cell integrity. β-lactams antibiotics disturb this balance, leading to their bactericidal effects.
Open in Who Shared Issue with article?

Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease

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By Viktor Hundtofte Mebus, Larissa M. Busch, Morten Boerre, Tobias K. Nielsen
| BioRxiv
Abstract A defining feature of bacteria is the peptidoglycan cell wall which provides structural integrity and prevents osmotic lysis. While peptidoglycan hydrolases are required for daughter cell separation, dysregulated cell wall degradation may result in cell lysis. The mechanisms allowing bacteria to control these deadly enzymes in response to environmental changes remain incompletely understood.
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