Vincent U. Gant

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Abstract ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures. While several studies demonstrate that loss of ATRX sensitizes cells to chemical stabilizers of G4 structures, the molecular function of ATRX at G4 regions during replication remains unknown.

Brown, A. L., de Smith, A. J., Gant, V. U., Yang, W., Scheurer, M. E., Walsh, K. M., Chernus, J. M., Kallsen, N. A., Peyton, S. A., Davies, G. E., Ehli, E. A., Winick, N., Heerema, N. A., Carroll, A. J., Borowitz, M. J., Wood, B. L., Carroll, W. L., Raetz, E. A., Feingold, E., Devidas, M., Barcellos, L. F., Hansen, H. M., Morimoto, L., Kang, A. Y., Smirnov, I., Healy, J., Laverdière, C., Sinnett, D., Taub, J. W., Birch, J. M., Thompson, P., Spector, L. G., Pombo-de-Oliveira, M. S., DeWan, A. T., Mullighan, C.