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Articles by Vinod Rane
Lupus Ups Atherosclerosis Risk, But Disease Remission Helps
TOPLINE: Patients with systemic lupus erythematosus (SLE) face more than double the risk for atherosclerotic plaque progression than healthy control individuals without the condition, but management of traditional cardiovascular risk factors and prolonged clinical remission can successfully mitigate it.
La budesonida a largo plazo muestra una eficacia sostenida en la esofagitis eosinofílica
Editado por Vinod Rane CONCLUSIÓN PRÁCTICA Los comprimidos bucodispersables de budesonida mantienen la remisión y mejoran la calidad de vida en la mayoría de adultos con esofagitis eosinofílica durante un máximo de 144 semanas. DISEÑO DEL ESTUDIO Existe una necesidad urgente de datos a largo plazo sobre la farmacoterapia en la esofagitis eosinofílica, dado que los pacientes con esta enfermedad crónica a menudo experimentan recaídas tras la interrupción del tratamiento.
Disc Degeneration in Chronic Low Back Pain: Can Stem Cells Help?
TOPLINE: Allogeneic bone marrow–derived mesenchymal stromal cells (BM-MSCs) are safe but do not show efficacy in treating intervertebral disc degeneration (IDD) in patients with chronic low back pain. METHODOLOGY: The RESPINE trial assessed the efficacy and safety of a single intradiscal injection of allogeneic BM-MSCs in the treatment of chronic low back pain caused by single-level IDD.
Controlar seis factores de riesgo puede combatir la enfermedad renal crónica en la obesidad
CONCLUSIÓN PRÁCTICA El control óptimo de la presión arterial, los niveles de hemoglobina glucosilada (HbA1c), el colesterol de lipoproteínas de baja densidad (c-LDL), la albuminuria, el tabaquismo, así como la actividad física pueden reducir el exceso de riesgo de enfermedad renal crónica típicamente asociado a la obesidad. El efecto protector es más pronunciado en los hombres, en las personas con menor puntuación en alimentación saludable y en los usuarios de medicación para la diabetes.
Controlling Six Risk Factors Can Combat CKD in Obesity
Publish date: September 19, 2024 TOPLINE: Optimal management of blood pressure, A1c levels, low-density lipoprotein cholesterol (LDL-C), albuminuria, smoking, and physical activity may reduce the excess risk for chronic kidney disease (CKD) typically linked to obesity. The protective effect is more pronounced in men, in those with lower healthy food scores, and in users of diabetes medication.
Current Hydroxychloroquine Use in Lupus May Provide Protection Against Cardiovascular Events
TOPLINE: Current use of hydroxychloroquine is associated with a lower risk for myocardial infarction (MI), stroke, and other thromboembolic events in patients with systemic lupus erythematosus (SLE). This protective effect diminishes after discontinuation of hydroxychloroquine treatment. METHODOLOGY: Researchers used a nested case-control design to evaluate the association between exposure to hydroxychloroquine and the risk for cardiovascular events in patients with SLE.
Inquinamento atmosferico e genetica si combinano per aumentare il rischio di lupus
IN SINTESI L'esposizione cronica a inquinanti atmosferici come il particolato fine con diametro di 2,5 ¼m (PM2,5), il particolato con diametro di 10 ¼m (PM10), il biossido di azoto (NO2) e gli ossidi di azoto (NOx) ha aumentato il rischio di insorgenza del lupus eritematoso sistemico (LES). Il rischio era più elevato tra i soggetti con alto rischio genetico e alta esposizione all'inquinamento atmosferico.
La hidroxicloroquina reduce el riesgo cardiovascular en el lupus
CONCLUSIÓN PRÁCTICA El tratamiento activo con hidroxicloroquina se asocia con un menor riesgo de infarto de miocardio, ictus y otros eventos tromboembólicos en pacientes con lupus eritematoso sistémico. Este efecto protector disminuye tras la interrupción del tratamiento con hidroxicloroquina.
Lo stile di vita sedentario vi sta uccidendo? Un nuovo studio dice di sì
CONCLUSIONI Durante un follow-up mediano di 14,3 anni, sono stati registrati 885 (15%) decessi per tutte le cause. Il rischio di mortalità per tutte le cause era del 47% più alto nei partecipanti con un impegno minore nella PA e una ST più alta (PASTBI basso) rispetto a quelli con un impegno maggiore nella PA e una ST più bassa (PASTBI alto; hazard ratio aggiustato, 1,47; 95% CI, 1,21-1,79).
El dupilumab es seguro y eficaz durante 5 años en la dermatitis atópica de moderada a grave
CONCLUSIÓN PRÁCTICA Durante 5 años, dupilumab demostró una seguridad aceptable y una eficacia sostenida, con mejoras significativas en los signos y los síntomas de la dermatitis atópica en el tratamiento de la dermatitis atópica de moderada a grave.
Bacteremia in NICU Linked to Increased Mortality Risk
TOPLINE: Hospital-onset bacteremia (HOB) in the neonatal intensive care unit (NICU) is associated with increased mortality, according to a study that also identified birth weight and postnatal age as risk factors for HOB. METHODOLOGY: This multicenter retrospective cohort study was conducted from 2016 to 2021 and included 451,443 infants (55.6%, men; 44.4% women) admitted to seven academically affiliated NICUs and 315 NICUs in the Pediatrix Medical Group for ≥ 4 days.
Las hormonas sexuales se relacionan con la esteatosis hepática en hombres con diabetes de tipo 2
Vinod Rane Resúmenes de artículos 12 jul. 2024 El acceso al contenido completo es sólo para profesionales sanitarios registrados. El acceso al contenido completo es sólo para profesionales sanitarios registrados.
Sex Hormones Linked to Fatty Liver in Men With T2D
Publish date: June 28, 2024 TOPLINE: In men with type 2 diabetes (T2D), higher serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were associated with a lower risk for metabolic dysfunction–associated fatty liver disease (MAFLD), whereas higher progesterone levels were associated with a higher risk. In women with T2D, sex- or thyroid-related hormones were not independently associated with the risk for MAFLD.
Sex Hormones Linked to Fatty Liver in Men With T2D
TOPLINE: In men with type 2 diabetes (T2D), higher serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were associated with a lower risk for metabolic dysfunction–associated fatty liver disease (MAFLD), whereas higher progesterone levels were associated with a higher risk. In women with T2D, sex- or thyroid-related hormones were not independently associated with the risk for MAFLD.
La enfermedad de Sjögren primaria favorece la aterogénesis prematura
CONCLUSIÓN PRÁCTICA Los pacientes con enfermedad de Sjögren primaria tienen un mayor riesgo de sufrir aterosclerosis subclínica temprana y más grave, particularmente aquellos con afectación de órganos. DISEÑO DEL ESTUDIO La inflamación crónica contribuye al desarrollo de aterosclerosis y mayores tasas de eventos cardiovasculares en pacientes con artritis reumatoide y lupus eritematoso sistémico.
Primary Sjögren Disease Promotes Premature Atherogenesis
TOPLINE: Patients with primary Sjögren disease (pSjD) are at an increased risk for early and more severe subclinical atherosclerosis, particularly those with organ involvement.
¿Sienten más dolor los adultos con obesidad?
Para examinar la asociación entre el sobrepeso o la obesidad y las intensidades de dolor autopercibidas, los investigadores realizaron un metanálisis de 22 estudios que incluían a 31.210 adultos mayores de 18 años y procedentes de diversas cohortes internacionales. Los participantes se clasificaron según su índice de masa corporal (IMC) en peso normal (18,5-24,9), sobrepeso (25,0-29,9) y obesidad (≥30). Un IMC ≥25 se consideró peso excesivo.
Do Adults With Obesity Feel Pain More Intensely?
Publish date: April 9, 2024 TOPLINE: Adults with excess weight or obesity tend to experience higher levels of pain intensity than those with a normal weight, highlighting the importance of addressing obesity as part of pain management strategies. METHODOLOGY: Obesity may cause pathophysiological changes, such as increased load on joints and systemic inflammation, potentially affecting the sensation of pain.
Gli adulti obesi sentono il dolore più intensamente?
Rispetto alle persone con peso normale, le persone con peso in eccesso (sovrappeso o obesità; differenza media standardizzata [SMD], -0,15; P = .0052) o con obesità (SMD, -0,22; P = .0008) hanno riferito intensità di dolore più elevate, con un effetto di piccole dimensioni. Il confronto del dolore auto-riferito nelle persone di peso normale e in quelle in sovrappeso non ha mostrato alcuna differenza statisticamente significativa.
El ejercicio más farmacoterapia, la mejor combinación para mantener la pérdida de peso
Vinod Rane Resúmenes de artículos 9 abr. 2024 El acceso al contenido completo es sólo para profesionales sanitarios registrados. El acceso al contenido completo es sólo para profesionales sanitarios registrados. Conclusión práctica La adición de ejercicio supervisado a la farmacoterapia para la obesidad ha demostrado un mayor potencial para mantener la pérdida de peso y mejorar la composición corporal tras finalizar el tratamiento que la farmacoterapia por sí sola.
Do Adults With Obesity Feel Pain More Intensely?
Adults with excess weight or obesity tend to experience higher levels of pain intensity than those with a normal weight, highlighting the importance of addressing obesity as part of pain management strategies. Obesity may cause pathophysiological changes, such as increased load on joints and systemic inflammation, potentially affecting the sensation of pain. Recent studies suggest that obesity may change pain perception and worsen existing painful conditions.
Argatrobán combinado mejora la recuperación funcional en el ictus
Los investigadores realizaron un metanálisis de 11 estudios (tres ensayos controlados aleatorizados y ocho estudios de cohortes retrospectivos), que incluyeron 8.635 pacientes con ictus agudo, de los cuales 3.999 (46,3 %) recibieron argatrobán más tratamiento antiplaquetario o alteplasa y 4.636 (53,7 %) no recibieron este tratamiento (grupo de control).
Exercise Plus Pharmacotherapy Better for Keeping Off Weight
Publish date: March 26, 2024 TOPLINE: The addition of supervised exercise to obesity pharmacotherapy has shown greater potential for maintaining weight loss and improving body composition after treatment termination than pharmacotherapy alone. METHODOLOGY: Despite significant weight loss achieved with incretin-based obesity pharmacotherapies, their high costs and gastrointestinal adverse events lead to high discontinuation rates with subsequent regaining of weight and body fat.
Exercise Plus Pharmacotherapy Better for Keeping Off Weight
TOPLINE: The addition of supervised exercise to obesity pharmacotherapy has shown greater potential for maintaining weight loss and improving body composition after treatment termination than pharmacotherapy alone. METHODOLOGY: Despite significant weight loss achieved with incretin-based obesity pharmacotherapies, their high costs and gastrointestinal adverse events lead to high discontinuation rates with subsequent regaining of weight and body fat.
Exercise Plus Pharmacotherapy Better for Keeping Off Weight
The addition of supervised exercise to obesity pharmacotherapy has shown greater potential for maintaining weight loss and improving body composition after treatment termination than pharmacotherapy alone. Despite significant weight loss achieved with incretin-based obesity pharmacotherapies, their high costs and gastrointestinal adverse events lead to high discontinuation rates with subsequent regaining of weight and body fat.
Argatroban Combo Improves Functional Recovery in Stroke
TOPLINE: Argatroban combined with antiplatelet therapy significantly improves functional recovery at 90 days, without increasing the risk for bleeding. METHODOLOGY: While argatroban has been shown to improve neurologic symptoms and daily activities in patients with acute ischemic stroke, it is unclear if combining it with antiplatelet or alteplase thrombolytic treatment in these patients provides additional beneficial.
Exercise Linked to Lower Kidney Disease Risk in Diabetes Original
Higher weekly levels of moderate physical activity are associated with a lower risk for chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and obesity or overweight. The long-term effect of moderate or vigorous physical activity on progression to CKD among patients with T2D has been unclear; the US and World Health Organization guidelines recently recognized health benefits of short bouts of activity lasting < 10 minutes.
Effect of Metformin Across Renal Function States in Diabetes
Publish date: March 5, 2024 TOPLINE: Metformin cuts the risk for diabetic nephropathy (DN) and major kidney and cardiovascular events in patients with newly diagnosed type 2 diabetes (T2D) across various renal function states. METHODOLOGY: Metformin is a first-line treatment in US and South Korean T2D management guidelines, except for patients with advanced chronic kidney disease (CKD) (stage, ≥ 4; estimated glomerular filtration rate [eGFR], < 30).
Effect of Metformin Across Renal Function States in Diabetes
Metformin cuts the risk for diabetic nephropathy (DN) and major kidney and cardiovascular events in patients with newly diagnosed type 2 diabetes (T2D) across various renal function states. Metformin is a first-line treatment in US and South Korean T2D management guidelines, except for patients with advanced chronic kidney disease (CKD) (stage, ≥ 4; estimated glomerular filtration rate [eGFR], < 30).
Risk of Serious Head Injuries Higher in Elderly
TOPLINE: Older patients with traumatic blunt head injuries have a high risk for serious intracranial injuries even with low-risk mechanisms of injury, such as ground-level falls. METHODOLOGY: Traumatic brain injuries (TBIs) are common among older patients with trauma, with older patients accounting for 48%-56% of TBI-related hospitalizations, according to recent estimates. However, limited specific data are available on the clinical effects of TBI in older patients.
Post-Bariatric Surgery Weight Loss Improves Thyroid Function
A year after bariatric surgery, greater weight loss is linked to measures of improved thyroid function in euthyroid patients with obesity. Obesity is associated with higher levels of thyroid-stimulating hormone (TSH) than normal weight, but changes in TSH and thyroid hormones after bariatric surgery in euthyroid individuals are still debatable.
Thiamine Offers Renal Protection in Septic Shock
TOPLINE: Intravenous thiamine supplementation causes a decline in renal replacement therapy (RRT) requirement in patients with septic shock, particularly in those with thiamine deficiency. METHODOLOGY: Renal injury is common in patients with septic shock. In previous studies, although the effects of thiamine supplementation were evaluated in patients with septic shock, renal outcomes were not specifically assessed.
Premeal Stomach-Filling Capsule Effective for Weight Loss
Oral intragastric expandable capsules taken twice daily before meals reduce body weight in adults with overweight or obesity compared with placebo, with mild gastrointestinal adverse events. Numerous anti-obesity pharmacotherapies have demonstrated effectiveness in reducing weight, but they may lead to side effects.
Prostate Risks Similar for Testosterone Therapy and Placebo
Publish date: January 19, 2024 TOPLINE: In middle-aged and older men with hypogonadism, excluding those at high prostate cancer risk, testosterone replacement therapy (TRT) showed low rates of adverse prostate events, including cancer. METHODOLOGY: Uncertainty and concern exist about a link between prostate cancer risk and testosterone levels. Most professional society guidelines recommend against TRT in men with a history of or an increased risk for prostate cancer.
Prostate Risks Similar for Testosterone Therapy and Placebo
TOPLINE: In middle-aged and older men with hypogonadism, excluding those at high prostate cancer risk, testosterone replacement therapy (TRT) showed low rates of adverse prostate events, including cancer. METHODOLOGY: Uncertainty and concern exist about a link between prostate cancer risk and testosterone levels. Most professional society guidelines recommend against TRT in men with a history of or an increased risk for prostate cancer.
Prostate Risks Similar for Testosterone Therapy and Placebo
In middle-aged and older men with hypogonadism, excluding those at high prostate cancer risk, testosterone replacement therapy (TRT) showed low rates of adverse prostate events, including cancer. Uncertainty and concern exist about a link between prostate cancer risk and testosterone levels. Most professional society guidelines recommend against TRT in men with a history of or an increased risk for prostate cancer.
Blood Pressure, Hypertension, and Atrial Fibrillation Risk: What’s the Association?
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 27 January 2023 Takeaway Patients with hypertension had an increased risk of developing atrial fibrillation (AF) compared with those without hypertension. An increase in systolic and diastolic blood pressure (BP) even within the normal range was linked to a higher risk of AF. Patients with higher systolic and diastolic BP had a 2-fold higher risk of AF.
Younger Age at Diabetes Diagnosis Linked to Higher Risk of Depression
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 23 January 2023 Takeaway Younger age at type 2 diabetes (T2D) diagnosis was associated with higher levels of depressive symptoms and diabetes-specific distress as well as lower levels of self-compassion. Why This Matters Findings emphasise the need for clinical vigilance and the availability of age-appropriate psychosocial support to improve the psychological well-being of younger adults with T2D.
Short Sleep Duration Tied to a Higher Risk of Multimorbidity
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 28 October 2022 Takeaway Short sleep duration in midlife and old age was associated with a higher risk of the onset of chronic disease and multimorbidity. Why This Matters Findings support the promotion of good sleep hygiene in both primary and secondary prevention of chronic disease and multimorbidity by targeting behavioural and environmental conditions that affect sleep duration and quality.
Patients With Cancer Are at a Lower Risk of Dementia
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 12 October 2022 Takeaway Patients with cancer had a lower risk of all-cause dementia and its subtypes such as Alzheimer’s disease and vascular dementia. However, non-melanoma skin cancer and prostate cancer were associated with a lower risk of all-cause dementia, but not Alzheimer’s disease and vascular dementia.
Early or delayed menopause and irregular periods tied to new-onset atrial fibrillation
FROM JAMA NETWORK OPEN Takeaway Early or delayed menopause and a history of irregular menstrual cycles were significantly associated with a greater risk of new-onset atrial fibrillation (AF) in women. Women with nulliparity and multiparity had a greater risk of new-onset AF compared with those with one to two live births. Why this matters Findings highlight the significance of considering the reproductive history of women while developing tailored screening and prevention strategies for AF.
Higher Risk of COVID-19 Diagnosis and Mortality With Folic Acid Supplementation
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 31 August 2022 Takeaway The prescription of folic acid supplementation was associated with a higher risk of COVID-19 diagnosis and mortality. However, the prescription of methotrexate was not associated with an increased risk of COVID-19 diagnosis.
Visual, Hearing, and Dual Sensory Impairment Associated With Higher Mortality Risk
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 30 August 2022 Takeaway Individuals with dual sensory impairment (DSI) and single hearing or visual impairment had a significantly higher risk of 14-year mortality than those without sensory impairment, irrespective of age, sex, and other confounders.
Does Calcitriol Improve Arterial Stiffness in Patients With T2DM and CKD?
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 17 August 2022 Takeaway In patients with type 2 diabetes mellitus (T2DM) and stage III chronic kidney disease (CKD), active vitamin D (calcitriol) did not show any significant reduction in aortic-pulse wave velocity (Ao-PWV), indices of central arterial stiffness, or albuminuria.
Vitamin D Levels Linked to COVID-19 Infection Risk
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 16 August 2022 Takeaway Low serum vitamin D levels were significantly associated with an increased risk of acquiring COVID-19 infection. Comorbidities such as diabetes, hypertension, chronic lung disease, and cardiovascular disease were not associated with a higher risk of COVID-19 infection.
SGLT-2 Inhibitors Do Not Increase Major Osteoporotic Fracture Risk
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 10 August 2022 Takeaway Current use of sodium-glucose co-transporter-2 (SGLT-2) inhibitors was not associated with a higher risk of major osteoporotic fracture risk compared with the use of sulphonylureas, irrespective of change in body mass index (BMI). Exposure to high cumulative doses of SGLT-2 inhibitors was found to be associated with a higher risk of osteoporotic fracture.
What's the Link Between Vitamin D Level and Cardiometabolic Risk Factors?
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 05 August 2022 Takeaway This study found an inverse association between serum 25-hydroxyvitamin D (25[OH]D) and a composite score of the metabolic syndrome and glycaemic markers. The inverse association between serum 25(OH)D and fasting blood glucose (BG) remained significant after adjustment for potential confounders.
Fish Oil Supplements May Protect Against Inflammatory Bowel Disease
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 04 August 2022 Takeaway The habitual use of fish oil supplements was associated with a reduced risk of the incidence of inflammatory bowel diseases (IBDs) and its subtype ulcerative colitis (UC). Fish oil supplementation use was inversely associated with baseline C-reactive protein (CRP) levels and positively associated with baseline albumin levels.
Review of Semaglutide in Type 2 Diabetes
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 26 July 2022 Takeaway In patients with type 2 diabetes (T2D), oral semaglutide was non-inferior to subcutaneous (SC) semaglutide and superior to placebo and other glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in reducing glycated haemoglobin (HbA1c) level and body weight.
Type 1 Diabetes Increases the Risk of Obstructive Sleep Apnoea
This site is intended for UK healthcare professionals Clinical Summary | Disclosures | 25 July 2022 Takeaway Patients with vs without type 1 diabetes had an increased risk of obstructive sleep apnoea. Obesity, male sex, older age, depression, atrial fibrillation, and the use of lipid-lowering and antihypertensive drugs were the risk factors for obstructive sleep apnoea in patients with type 1 diabetes.
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