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Vinodh Rajagopalan on Muck Rack

Vinodh Rajagopalan

As seen in: Nature
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Articles

RAS inhibition limits oncogenic signaling and tumorigenesis in neuroblastoma regardless of RAS mutational status

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By Rachel Greathouse, Tarah Elizabeth Trebino, Gayatri Ketavarapu, Akiko Koide, Fiona E. Hood, Ian Prior, Mark R. Philips, Shohei Koide, Bill Chiu, John O’bryan, Mubashir Mintoo, Vinodh Rajagopalan, Cecile Nasarre, Dianicha Santana, Kevin O. Flores-Galvez
| Nature Verified
Abstract Neuroblastoma (NBL) is a rare and aggressive pediatric malignancy with a 5-year survival rate of 40–50% for patients diagnosed with high-risk disease. NBLs arise in the sympathetic nervous system and causes 11% of all pediatric cancer deaths. MYCN amplification or overexpression drives 22% of NBL cases while deregulation of genes including c-MYC, ALK, PHOX2B, and LIN28B also plays a critical role in NBL initiation and progression.
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