Vinona Muralidaran on Muck Rack

Vinona Muralidaran

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Circulating, cell-free methylated DNA indicates cellular sources of allograft injury after liver transplant

|
By Meg McNamara, Sidharth S. Jain, Kesha Oza, Vinona Muralidaran
| biorxiv.org
Abstract Post-transplant complications reduce allograft and recipient survival. Current approaches for detecting allograft injury non-invasively are limited and do not differentiate between cellular mechanisms. Here, we monitor cellular damages after liver transplants from cell-free DNA (cfDNA) fragments released from dying cells into the circulation. We analyzed 130 blood samples collected from 44 patients at different time points after transplant.
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