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Viralkumar Davra on Muck Rack

Viralkumar Davra

As seen in: BioRxiv, Molecular Cancer Research, The Journal of Immunology
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Articles

Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications

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By Varsha Gadiyar, Viralkumar Davra, Rachael Pulica, Trevor Frederick
| BioRxiv
Abstract In viable healthy cells, membrane phospholipids are asymmetrically distributed across the lipid bilayer, whereby the anionic phospholipid phosphatidylserine is virtually all distributed on the inner leaflet of the plasma membrane. During apoptosis, phospholipid asymmetry collapses and PS is externalized to the external leaflet where it serves as an eat-me signal for efferocytosis, the process whereby dying cells are engulfed and degraded by phagocytes.
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Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production | The Journal of Immunology

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By David Calianese, Tamara Kreiss, Canan Kasikara, Viralkumar Davra
| The Journal of Immunology Verified
David Calianese, Tamara Kreiss, Canan Kasikara, Viralkumar Davra, Kevin C. Lahey, Varsha Gadiyar, Ke Geng, Sukhwinder Singh, William Honnen, Dabbu Kumar Jaijyan, Charles Reichman, John Siekierka, Maria Laura Gennaro, Sergei V. Kotenko, David S. Ucker, Rolf A. Brekken, Abraham Pinter, Raymond B. Birge and Alok Choudhary J Immunol July 15, 2021, 207 (2) 436-448; DOI: https://doi.org/10.4049/jimmunol.2000763 Key Points PS-targeting mAbs 11.31 and Bavi bind external PS on anti-CD3/CD28 activated T cells.
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Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production | The Journal of Immunology

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By David Calianese, Canan Kasikara, Viralkumar Davra, Tamara Kreiss
| The Journal of Immunology Verified
David Calianese, Tamara Kreiss, Canan Kasikara, Viralkumar Davra, Kevin C. Lahey, Varsha Gadiyar, Ke Geng, Sukhwinder Singh, William Honnen, Dabbu Kumar Jaijyan, Charles Reichman, John Siekierka, Maria Laura Gennaro, Sergei V. Kotenko, David S. Ucker, Rolf A. Brekken, Abraham Pinter, Raymond B. Birge and Alok Choudhary J Immunol July 2, 2021, ji2000763; DOI: https://doi.org/10.4049/jimmunol.2000763 Key Points PS-targeting mAbs 11.31 and Bavi bind external PS on anti-CD3/CD28 activated T cells.
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