Skip To Main Content
Virinder Reen on Muck Rack

Virinder Reen

As seen in: Nature, Science Magazine
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Virinder

Contact Virinder, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

The anion channel GPR89 is a tumor-specific dependency in breast cancer

|
By Riccardo Ferro, Alexandra Nicewicz Carroll, Virinder Reen, George Vlachogiannis, Rebeca Uceda-Castro, Dragomir B. Krastev, Valeria Amodeo, Stephen Pettitt, Nadja D’Uonno, Ioanna Mavrommati, Blanca Navarro, Luke Hitchen, Jennifer Trendell, Ana Stojiljkovic, Cynthia Prince, Ioannis Roxanis, Patrycja Gazinska, Daniel Larcombe-Young, Rebecca Marlow, Stefano Annunziato, Jos Jonkers, Nalan Liv, John Alexander, Jelmar S. Quist, Mercedes Pardo, Theodoros I. Roumeliotis, Jyoti Choudhary, Daniel Weekes, Joanna I Loizou, Rachael Natrajan, Anita Grigoriadis, Syed Imran Haider, Christopher Lord Verified, Andrew Tutt, Ana M. Mendes-Pereira, Narinder Janghra, Tejashree Rajaram Kanitkar, Amadeus Xu, Nirmesh Patel, Pierfrancesco Marra, Mallur Srivatsan Madhusudhan
| Nature Verified
Abstract How cancers regulate endoplasmic reticulum (ER) pH and minimize ER stress remains unclear. Here we show that in breast cancer, these processes are governed by the anion channel GPR89. While normally localized to the Golgi, we find GPR89 is also present in the ER of tumor cells, where it collaborates with vacuolar H⁺ ATPase to regulate pH, and reduces ER stress via IRE1α-HSP47-XBP1s, ATF6 and ATP2A2 pathways.
Open in Who Shared Issue with article?

SMARCA4 regulates the NK-mediated killing of senescent cells

|
By Suravi Ray, Max-Philipp Stenner, Shingo Soya, Virinder Reen
| Science Magazine Verified
Abstract Induction of senescence by chemotherapeutic agents arrests cancer cells and activates immune surveillance responses to contribute to therapy outcomes. In this investigation, we searched for ways to enhance the NK-mediated elimination of senescent cells. We used a staggered screen approach, first identifying siRNAs potentiating the secretion of immunomodulatory cytokines to later test for their ability to enhance NK-mediated killing of senescent cells.
Open in Who Shared Issue with article?
See all 2 articles