Vishavdeep Vashisht on Muck Rack

Vishavdeep Vashisht

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Articles

Exploring force-driven stochastic folding dynamics in mechano-responsive proteins and implications in phenotypic variation - Nature Communications

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By Ojas Singh, Amin Sagar, Vishavdeep Vashisht
| Nature Verified
Abstract Single-point mutations are pivotal in molecular zoology, shaping functions and influencing genetic diversity and evolution. Here we study three such genetic variants of a mechano-responsive protein, cadherin-23, that uphold the structural integrity of the protein, but showcase distinct genotypes and phenotypes. The variants exhibit subtle differences in transient intra-domain interactions, which in turn affect the anti-correlated motions among the constituent β-strands.
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