Skip to main content
Vishawjeet Barik on Muck Rack

Vishawjeet Barik

As seen in: Nature, BioRxiv
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Vishawjeet

Contact Vishawjeet, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

A pH-dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis - Communications Biology

|
By Vaibhav Kumar Nain, Vishawjeet Barik, Shailendra Asthana
| Nature Verified
Abstract Methionine is essential for the growth and survival of Mycobacterium tuberculosis (M. tuberculosis), however, the canonical transsulfuration pathway involved in the biosynthesis of methionine is dispensable, suggesting redundancy. This study explores the presence of an ortholog of O-succinyl homoserine sulfhydrylase in M. tuberculosis, which catalyses direct sulfhydrylation for methionine biosynthesis.
Open in Who Shared Issue with article?

pH dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis

|
By Vaibhav Kumar Nain, Vishawjeet Barik, Manitosh Pandey
| BioRxiv
Abstract Methionine is essential for the survival of Mycobacterium tuberculosis (M. tuberculosis) inside the host. However, the transsulfuration pathway, a major contributor of methionine, is dispensable for the growth of M. tuberculosis suggesting redundancy in the methionine biosynthesis pathway. Orthologues of MetZTB in other bacterial species are known to operate a redundant single-step methionine biosynthesis pathway called direct sulfhydrylation.
Open in Who Shared Issue with article?

pH dependent direct sulfhydrylation pathway is required for pathogenesis of Mycobacterium tuberculosis

|
By Vaibhav Kumar Nain, Manitosh Pandey, Vishawjeet Barik
| BioRxiv
Abstract Methionine is essential for the survival of Mycobacterium tuberculosis (M. tuberculosis) inside the host. Inhibiting the transsulfuration pathway fails to exhibit methionine auxotrophy suggesting the presence of an alternate methionine biosynthesis pathway in M. tuberculosis. Orthologues of MetZTB in other bacterial species are known to regulate a redundant single step methionine biosynthesis pathway known as direct sulfhydrylation.
Open in Who Shared Issue with article?
See all 3 articles