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Viviane Bes

As seen in: Nature
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Articles

Pannexin1-dependent and -independent protection by novel peptidomimetics against cardiac ischemia/reperfusion injury

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By Malaury Tournier, Arthur Lamouroux, Laureano E. Carpio, Debora Iaculli, Maral Azam, Mathieu Vinken, Rafael Gozalbes, Filippo Molica, Steven Ballet, Viviane Bes, Brenda R. Kwak
| Nature Verified
Abstract Myocardial infarction necessitates rapid reperfusion to limit ischemic damage. However, reperfusion itself exacerbates cardiomyocyte death and the inflammatory response. ATP release through pannexin1 (Panx1) channels is a key driver of leukocyte recruitment, yet most Panx1 channel inhibitors lack specificity or in vivo stability.
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