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Vlachaki Walker

As seen in: Color Research & Application
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Articles

Macrophages amplify spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain

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By Vlachaki Walker
| gla.ac.uk
Chrysostomidou, P. et al. (2026) Macrophages amplify spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain. Brain, (doi: 10.1093/brain/awag088) (PMID:41793058) (Early Online Publication) Text 381645.pdf - Accepted Version Available under License Creative Commons Attribution. 2MB Abstract Neuropathic pain is a highly prevalent condition for which treatments are hampered by low efficacy and dose-limiting side-effects.
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AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner

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By Vlachaki Walker, Weightman Potter, Michael L. J., Kate L. J.
| Color Research & Application Verified
Astrocytes are the main sources of extracellular ATP (eATP) within the brain, which functions as a gliotransmitter, capable of modulating neuronal and astrocytic activity. These cells play an important role in regulating energy homeostasis partly via astrocyte-derived ATP. Given the role of AMPK in regulating intracellular ATP levels, we hypothesised that AMPK may alter ATP release from astrocytes.
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