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Volkher Scharnhorst on Muck Rack

Volkher Scharnhorst

As seen in: Nature, Wiley Online Library
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Articles

The association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke

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By Birgit A.L.M. Deiman, Mike Hermans, Maarten De Rijk, Volkher Scharnhorst, Anne Bras
| Nature Verified
Abstract Clopidogrel therapy is recommended to prevent recurrent ischemic stroke. However, clopidogrel resistance exists. This study examines which enzymes are involved in clopidogrel resistance. The study group includes 402 neurology patients who had experienced a recurrent ischemic stroke while receiving clopidogrel monotherapy. Patients were genotyped for CYP2C19, CYP2C9, CYP2B6, CYP3A4, CYP3A5, CYP1A2, ABCB1 and CES1A1.
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Unexplained Elevated Vitamin B12: Consider Macro‐B12

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By Ruben Deneer, Marten R. Nijziel, Volkher Scharnhorst
| Wiley Online Library Verified
1 Introduction Vitamin B12 (cobalamin) is a water-soluble vitamin that serves as a coenzyme in nucleotide synthesis. Due to high cell-turnover during erythropoiesis, vitamin B12 deficiency can result in pernicious anemia. After oral intake of animal products or supplementation, vitamin B12 binds to intrinsic factor, a glycoprotein produced by gastric parietal cells.
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Immunoaffinity Intact-Mass Spectrometry for the Detection of Endogenous Concentrations of the Acetylated Protein Tumor Biomarker Neuron Specific Enolase

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By Luc Brunsveld, Volkher Scharnhorst, Iain D. G, den Boer
| dx.doi.org
The use of mass spectrometry as an alternative to immunoassay-based methods for the quantification of proteins is of great interest in the field of clinical chemistry. Commonly, bottom-up strategies are used in which proteins are digested into proteotypic peptides.
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