Volodimir Olexiouk

INTRODUCTION Precision diagnostics is a prerequisite for precision medicine by enabling a characterization of diseases on a molecular level leading to a mechanism-based treatment. Giving the right drug to the right patient at the right dose and at the right time requires novel biomarker signatures to stratify patients accordingly. Diagnostics play an essential role in the context of drug repurposing, where existing drugs are investigated and repurposed for a new therapeutic use.

Record: found Abstract: found Conference Proceedings: found Is Open Access Author(s): Publication date (Electronic, pub): Conference name: RExPO23 Conference date: 25-26 October 2023 Keywords: , , , , , , Bookmark In the era of personalized healthcare, precision medicine stands out as a transformative approach, offering bespoke therapeutic strategies tailored to individual patient molecular profiles.

Abstract The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly expanding the known proteome at the lower end of the size distribution. Here, we show that the mitochondrial proteome, particularly the respiratory chain, is enriched for small proteins. Using a prediction and validation pipeline for SEPs, we report the discovery of 16 endogenous nuclear encoded, mitochondrial-localized SEPs (mito-SEPs).