von Niklas Baumgarten

Changing TSPO-PET signals of organs in glioblastoma-bearing mice compared to sham-injected mice First, to identify tumor-associated immune processes, we investigated [18F]GE-180 TSPO-PET signals in different VOIs of the mouse body (Fig. 1a). In mice with glioblastoma, TSPO-PET signal was significantly increased in the tumor region at both early (+ 59%, p = 0.0003) and late stages (+ 69%, p < 10− 6) compared to sham-injected mice (Fig. 1b).

Abstract Lung cancer brain metastasis has a devastating prognosis, necessitating innovative treatment strategies. While chimeric antigen receptor (CAR) T-cell show promise in hematologic malignancies, their efficacy in solid tumors, including brain metastasis, is limited by the immunosuppressive tumor environment. The PD-L1/PD-1 pathway inhibits CAR T-cell activity in the tumor microenvironment, presenting a potential target to enhance therapeutic efficacy.

This is a preview of subscription content, to check access. Get 10 units per month Download Article/Chapter or eBook 1 Unit = 1 Article or 1 Chapter Cancel anytime Price excludes VAT (USA) Tax calculation will be finalised during checkout. Instant access to the full article PDF. Rent this article via DeepDyve Supplementary Information About this article Blobner, J., Thon, N. & von Baumgarten, L. Zielgerichtete Therapie von Gliomen. Fokus Onkol 27, 54–58 (2024).