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Vyvyan Nguyen on Muck Rack

Vyvyan Nguyen

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Articles

The establishment of prostate-specific, SKP2 humanized mice by CRISPR knock-in method reveals neoplastic initiation and microenvironmental reprogramming

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By Liankun Song, Yurong Song, Shan Xu, Kelly Ho, Altaf Mohammed, Robert H. Shoemaker, Bang Hoang, Jianhua Yu, Edward Uchio, Xiaolin Zi, Vyvyan Nguyen
| Nature Verified
Abstract Genetic inactivation of SKP2 has been shown to effectively prevent cancer initiation and block tumorigenesis. However, direct in vivo evidence for SKP2 on cancer initiation and prostatic microenvironment is still lacking and a SKP2 humanized mouse model is critical for developing prostate cancer immunoprevention approaches through targeting SKP2. We therefore have established a prostate-specific human SKP2 knock-in mouse model driven by an endogenous mouse probasin promoter.
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