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W Andrew Yeudall on Muck Rack

W Andrew Yeudall

As seen in: eLife, Future Medicine
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Articles

A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer

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By Saima Usman, W Andrew Yeudall, Muy-Teck Teh, Fatemah Ghloum
| eLife
Vimentin is a type III intermediate filament (IF) protein normally expressed in mesenchymal cells. Due to its diverse pathophysiological role(s), it is one of the most extensively studied IFs. It has been proposed to play a role in epithelial-to-mesenchymal transition (EMT) and cancer metastasis [1].
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Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells

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By Hu Yang, Leyuan Xu, Shannon Kittrell, W Andrew Yeudall
| Future Medicine Verified
Aim: Folic acid (FA)-decorated polyamidoamine dendrimer G4 (G4-FA) was synthesized and studied for targeted delivery of genes to head and neck cancer cells expressing high levels of folate receptors (FRs). Methods: Cellular uptake, targeting specificity, cytocompatibility and transfection efficiency were evaluated. Results: G4-FA competes with free FA for the same binding site.
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