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Lower ejection fraction (EF) has been identified as a risk factor for increased mortality and morbidity following coronary artery bypass grafting (CABG). Patients with extremely low EF (≤20%) have been historically underrepresented in studies of surgical revascularization, and the role of CABG for these patients with heart failure remains debated in the current era of excellent outcomes following the placement of durable mechanical circulatory support.
Osteoarthritis (OA) is the primary cause of disability among the elderly, affecting over 400 million people globally [1], [2]. However, there are no effective medications to slow or reverse disease progression currently [3], [4], [5].
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