W Yin

BACKGROUND Left ventricular non-compaction cardiomyopathy (LVNC) is a congenital cardiomyopathy, characterized by excessive ventricular trabeculation, with a ‘spongy’ appearance of the myocardium, deep intertrabecular recesses, and a thin compacted myocardial layer. LVNC has recently gained more attention because it has been increasingly recognized as a cause of heart failure, thromboembolism, or ventricular arrhythmia, which can all lead to sudden cardiac death.

The synthetic compound NO-1886 (ibrolipim) is a lipoprotein lipase activator that has been proven to be highly effective in lowering plasma triglycerides. Recently, we found that NO-1886 also reduced plasma free fatty acids and glucose in high-fat/high-sucrose diet-induced diabetic rabbits. In the current study, we investigated the effects of NO-1886 treatment on ectopic lipid deposition and the islet pathology in miniature swine fed a high-fat/high-sucrose diet.