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Wainna Barroso Mendes on Muck Rack

Wainna Barroso Mendes

As seen in: Nature
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Articles

Canonical mTOR protein supports complete fin regeneration with selective effects on myeloid transcriptional programs

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By Josane F Sousa, Gabriela Lima, Louise Neiva Perez, Rutuparna Joshi, Rogério Gomes, Igor Schneider, Michaela Tsanova, Cyrus Bronson, Garrison Boehl, Icyss Sargeant, Aline C. Dragalzew, Wainna Barroso Mendes
| Nature Verified
Abstract The mechanistic target of rapamycin (mTOR) is a conserved regulator of cellular growth, metabolism, and tissue repair. Salamanders possess unique amino acid expansions in mTOR proposed to confer hypersensitive kinase activity, raising the possibility that canonical mTOR is insufficient to support complex appendage regeneration. We tested this hypothesis in the Senegal bichir (Polypterus senegalus), a ray-finned fish capable of complete fin regeneration.
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