Fig. 1: CRM1-AF10 and CRM1Δ-AF10 display leukemogenic activity. Fig. 2: Impairing the NUP214/CRM1 interaction abrogates leukemia development. References 1. Kumon K, Kobayashi H, Maseki N, Sakashita A, Sakurai M, Tanizawa A, et al. Mixed-lineage leukemia with t(10;11)(p13;q21): an analysis of AF10-CALM and CALM-AF10 fusion mRNAs and clinical features. Genes Chromosomes Cancer. 1999;25:33–9. CAS Article Google Scholar 2. Dik WA, Brahim W, Braun C, Asnafi V, Dastugue N, Bernard OA, et al.
