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Wakkas Fadhil on Muck Rack

Wakkas Fadhil

As seen in: Nature, Journal of Clinical Pathology, TechTrends
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Articles

Both CD8 + and CD4 + T regulatory cells are associated with poor survival in colorectal cancer

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By Zhiyuan Cheng, Wakkas Fadhil, Abhik Mukherjee, Ahmed Barakat, Anna Malecka, Andrew Jackson, Mohammad Ilyas, Ian Spendlove, Judith M. Ramage, Anthony Gyening-Yeboah
| Nature Verified
Abstract Previous studies in colorectal cancer have linked high levels of FoxP3+ regulatory T-cells (Treg) (CRC) to a favourable prognosis. However, this contradicts the well-established immunosuppressive function of Treg. We resolved this conundrum using multiplex immunohistochemistry to characterise Foxp3+and IL-10+ Treg in 1000 consecutively recruited patients’ tumours.
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Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific

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By Susanti Susanti, of Muhammadiyah Purwokerto, Wakkas Fadhil, Shamayal Murtaza
| Journal of Clinical Pathology Verified
Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific Susanti Susanti1,2,3, Wakkas Fadhil1,3, Shamayal Murtaza1, James C Hassall1,3, Henry O Ebili1,3,4, Anca Oniscu5, Mohammad Ilyas1,3 1 Molecular Pathology Group, Unit of Academic Molecular Pathology, Division of Cancer and Stem Cell, School of Medicine, University of Nottingham, Queen’s Medical Centre Campus, Nottingham, UK 2...
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Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific

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By Susanti Susanti, Wakkas Fadhil, of Muhammadiyah Purwokerto, Shamayal Murtaza
| Journal of Clinical Pathology Verified
Mutation in KRAS, BRAF and PIK3CA are commonly present in colorectal cancer (CRC). KRAS and BRAF form part of the mitogen-activated protein kinase (MAPK) signalling pathway and KRAS lies immediately upstream of BRAF.
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