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Waleed Barakat

As seen in: Biochemistry & Cell Biology
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Articles

Pentoxifylline abrogates cardiotoxicity induced by the administration of a single high dose or multiple low doses of doxorubicin in rats

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By Shimaa M. Elshazly, Amr A. A. Mahmoud, Waleed Barakat, a Waleed Barakatab
| Biochemistry & Cell Biology Verified
Doxorubicin (DOX) possesses a broad-spectrum antineoplastic activity; however, its clinical application is impeded by cardiotoxicity. This study aimed to investigate the protective effect of pentoxifylline (PXF), which possesses antioxidant and anti-inflammatory properties against cardiotoxicity induced by a single high dose (15 mg/kg, i.p.) or multiple low doses (2.5 mg/kg, i.p., three times per week for 2 weeks) of DOX.
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