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Waleed M. Kholosy on Muck Rack

Waleed M. Kholosy

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Articles

Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

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By Gerda Kildisiute, Matthew Young Verified, Kenny Roberts, Waleed M. Kholosy
| Science Magazine Verified
Abstract Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cells by comparing cancer (n = 19,723) with normal fetal adrenal single-cell transcriptomes (n = 57,972). Our principal finding was that the neuroblastoma cancer cell resembled fetal sympathoblasts, but no other fetal adrenal cell type.
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