Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Walter Hofer
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
The natural product chlorotonil displays high potency against multidrug-resistant Gram-positive bacteria and Plasmodium falciparum. Yet, its scaffold is characterized by low solubility and oral bioavailability but progress was recently made to enhance these properties. Applying late-stage functionalization, we aimed to further optimize the molecule. Previously unknown reactions including a sulfur-mediated dehalogenation were revealed.
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Introduction Natural products represent an important pool of chemical diversity to cover the need of new scaffolds in drug discovery.1, 2 These scaffolds have the major advantage of displaying wider structural diversity than most synthetically obtained libraries including clinically approved drugs.3 This diversity is often derived from evolutionary optimization for biological activity, and in most cases cannot be easily accessed by classic organic synthesis.
Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells
Highlights • Identification of a structurally novel inhibitor of the UNC119-Src interaction • Impairment of UNC119-medicated Src plasma membrane enrichment • Reduction of activating Src Y416 autophosphorylation • Reduction of growth and clonogenic potential of Src-dependent cells Summary Interference with the signaling activity of the N-myristoylated nonreceptor protein tyrosine kinase Src is considered a viable approach in anti-cancer drug discovery.
z.e.a. gmbh in Liquidation
Registered since 27 years Turnover in CHF Capital in CHF 20'000 Employees Active brands 0 Reports for z.e.a. gmbh in Liquidation *displayed reports are examples Credit rating information Evaluation of credit rating with traffic light as risk indicator and other helpful data about the company. Find out more Economic information Comprehensive information about the economic situation of a company. Find out more Payment behaviour Assessment of the payment behaviour based on past invoices.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Walter
Contact Walter, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack