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Wan-chao Yin on Muck Rack

Wan-chao Yin

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Metabolic checkpoint blockade of IL4I1 by ZY-MY-111 reactivates CD8 + T cell immunity and suppresses tumor growth

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By Hao Wang, Cheng-Cheng Xu, Zi-Xuan Li, Xiao-min Xu, Pei-Pei Wang, Yu-bo Zhou, Jia Li, Ju-fei Li, Yuan-chun Liu, Shao-hao Lin, Ming-zhi Wang, Wan-chao Yin
| Nature Verified
Abstract Metabolic hijacking of tryptophan (Trp) via the IL4I1-AHR axis is a pivotal immune evasion mechanism in cancers, yet therapeutic strategies to disrupt this pathway remain unexplored. Here, we report the identification of ZY-MY-111, a selective small-molecule inhibitor of interleukin-4-induced-1 (IL4I1), through an in-house compound library screening and structural optimization. ZY-MY-111 exhibits potency (IC50 = 1.86 ± 0.13 μM) in blocking IL4I1-mediated oxidative deamination.
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