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Wang Yizhou Tracy on Muck Rack

Wang Yizhou Tracy

As seen in: BioRxiv
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Articles

Quantitative and large-scale investigation of human TCR-HLA Cross-Reactivity

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By Mingyao Pan, Yuhao Tan, Jing Hu, Wang Yizhou Tracy
| BioRxiv
Abstract The interaction between Human leukocyte antigens (HLA) and T cell receptor (TCR) is essential for adaptive immune recognition. While it is known that one TCR can map to multiple HLA alleles, the extent of this cross-reactivity remains poorly understood. Here, we introduce THNet, a TCR-based HLA similarity inference method, and performed a comprehensive analysis of HLA-TCR cross-reactivity.
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