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Wangyun Xu

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Articles

Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury

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By Wu Bao, Bingqing Hang, Jiajie Mao, Lichao Wang, Guangyi Xu, Meng Wang, Kailin Liu, Xianjiong Chen, Xinyi Zhu, Guifang Li, Daqian Xu, Gaopeng Li, Yuan Ding, Qiming Liang, Xiaobing Dou, Jiaxin Chen, Jinshui Pan, Yanhui Lu, Yuhao Wang, Danyi Zeng, Li-Bin Pan, Wangyun Xu
| Nature Verified
Abstract Drug-induced liver injury (DILI) is a leading cause of acute liver failure, posing a significant public health burden. Emerging evidence underscores the gut microbiota as a critical environmental factor that profoundly influences liver function and DILI progression, yet the underlying mechanisms remain poorly understood. Here, we identify hepatic long non-coding RNA SNHG9 as a key mediator linking the gut microbiota to acetaminophen (APAP)-induced liver injury.
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