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Mechanism of Glycyrrhiza and glycyrrhetinic acid in cisplatin-induced acute kidney injury: a proteomics and metabolomics study
Abstract Background: Acute kidney injury (AKI) is a frequent and serious complication associated with cisplatin (CP), severely limiting its clinical use. Glycyrrhiza (GL) has been clinically used in China for detoxification, and its primary active ingredient, Glycyrrhetinic acid (GA), demonstrates detoxification effects. Studies conducted previously have shown that GL and GA offer protection against CP-induced AKI. However, the precise mechanism underlying this effect is unclear.
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