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Articles by Wanting Hou
Integrative spatial profiling pipeline for determining TME architectures in archival clinical specimens using CmTSA superplex technology
Abstract The tumor microenvironment (TME) comprises diverse cellular components that spatially interact to form distinct functional niches (FNs). Profiling these TME spatial features has proven to be a critical approach for correlating tumor progression and therapeutic response.
Lived experiences of patients with advanced pancreatic cancer on patient-reported outcomes (PROs) management: a qualitative phenomenological study in Southwest China
Each interview lasted approximately 17 min on average (range, 14–23 min). The interviews yielded abundant information, from which five overarching themes were generated, including ‘PROs management improves communication with healthcare providers’, ‘PROs management improves perceived sense of care’, ‘PROs management is helpful for treatment decision-making’, ‘PROs management is instrumental for communicating with family’ and ‘Possible but uncertain perceived quality of living benefits’.
The Demographic and Clinical Characteristics, Prognostic Factors, and Survival Outcomes of Head and Neck Carcinosarcoma: A SEER Database Analysis
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Pipeline for Assessing Tumor Immune Status Using Superplex Immunostaining and Spatial Immune Interaction Analysis
Abstract The characteristics of the tumor microenvironment (TME) are closely linked to tumor progression and treatment response. The TME comprises various cell types, their spatial distribution, cell-cell interactions, and their organization into cellular niches or neighborhoods. To capture this complexity, several spatial profiling technologies have been developed.
Predictive Biomarkers for Immunotherapy in Gastric Cancer: Current Status and Emerging Prospects
2.1. PD-L1 Expression as the Biomarker for GC Immunotherapy PD-L1 is a critical ligand protein expressed on tumor cells and tumor-associated antigen-presenting cells. Its binding to programmed death-1 (PD-1) on T cells leads to T cell deactivation, enabling tumor cells to evade the host’s immune response. ICIs targeting PD-L1 or PD-1 can interrupt this interaction, activating T-cell anti-tumor immunity [11].
Computational holographic ghost diffraction
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Dynamic Distribution of Skin Microorganisms in Donkeys at Different Ages and Various Sites of the Body
Abstract : Simple Summary Considerable evidence suggests that skin microbiota communities are critical for maintaining health and skin homeostasis. However, to date, studies on the skin microorganisms of donkeys are surprisingly rare. Therefore, the present study investigated the dynamic changes in commensal microbial communities (bacteria and fungal composition) on the skins of healthy donkeys throughout the growing period.
Vortex Speckles with Customized Symmetry and Spatial Correlations
Abstract A family of optical speckles with propagation-invariant annular morphology are generated via a phase-only mask and free-space evolution, termed vortex speckles, for which phase design is inspired by the vortex beam’s helical wave front carrying orbital angular momentum. Vortex beams’ graceful symmetry (central and/or axial) can be naturally inherited into vortex speckles by adjusting the parity of the topological value ℓ and the consistency of the initial phase angle ϕ0.
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