Xiaoying Li
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A Simple O-RADS-Based Ultrasound Scoring System for Risk Stratification of Ovarian Cystic Lesions: A Multicenter Study
Abstract Objective To develop and validate a simple and practical scoring system based on O-RADS ultrasound features for distinguishing benign from malignant ovarian cystic lesions. Methods This multi-institutional retrospective study included women with ovarian cystic lesions who underwent pelvic ultrasound and had either histopathological confirmation or at least 2 years of imaging follow-up.
Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study
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Abstract Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chemotherapy as a first-line treatment for patients with HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma (GA/GEJA).
By Mo Cheng, Pengfei Zhang, Qiancheng Hu, Jitao Zhou, Ruihong Dai, Wenke Li, Jing Wei, Menghui Xu, Yanna Lei, Xiaoying Li, Xiufeng Zheng, Qian Huang, Zhiping Li, Bo Zhang, Wen Zhuang, Zhixin Chen, Xiaolong Chen, Chaoyong Shen, Weihan Zhang, Kai Liu, Linyong Zhao, Xiaonan Yin, Zhaolun Cai, Yuan Yin, Ji Chen, Chunjuan Liu, Deying Kang, Mojin Wang, Hongfeng Gou, Kun Yang, Jiankun Hu, Feng Bi, Ming Liu Verified, Boqiang Peng
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Nature
Verified
qHBsAg Trajectories with Peg-IFNα-2b Add-on Therapy in Nucleos(t)ide Analog-experienced HBeAg-positive Chronic Hepatitis B
HBsAg loss is a preferred virological endpoint for functional cure in chronic hepatitis B (CHB), yet it remains uncommon within finite treatment durations, particularly under long-term nucleos(t)ide analogs (NAs) therapy. Pegylated interferon alpha-2b (Peg-IFNα-2b) may increase the probability of HBsAg decline and loss in selected patients; however, in small real-world cohorts, the limited number of HBsAg loss events often leads to imprecise estimates and uncertainty.
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