WANTING ZHAO

Tumor vaccines targeting carbonic anhydrase IX (CAIX) are a promising strategy for renal carcinoma but are frequently limited by an immunosuppressive tumor microenvironment that impairs effective T-cell responses. V-domain Ig suppressor of T-cell activation (VISTA) is an inhibitory immune checkpoint enriched in myeloid cells and regulatory T cells that contributes to tumor immune suppression and resistance to checkpoint blockade.

Prostate-specific membrane antigen (PSMA)-based vaccination is a promising strategy for prostate cancer but is often limited by tumor-induced immune suppression and suboptimal antigen presentation. Galectin-9 (LGALS9) regulates immune responses through the TIM-3 pathway and has been implicated in T-cell exhaustion and tumor immune evasion. Adenoviral vectors are effective platforms for inducing robust antigen expression and CD8+ T-cell responses in cancer immunotherapy.

Abstract With the global prevalence of diabetic kidney disease (DKD) continuing to rise, its early diagnosis remains challenging due to the limitations of existing clinical methods. This study integrates pathological diagnostic data using machine learning (ML), employing feature selection, multi-model comparison, and model evaluation to construct a high-precision early prediction model.